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Indication & Dosage |
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| Parenteral |
| SUSCEPTIBLE INFECTIONS INCLUDING RESPIRATORY TRACT INFECTIONS, INTRA-ABDOMINAL INFECTIONS, URINARY TRACT INFECTIONS, SKIN AND SOFT TISSUE, AND BONE AND JOINT INFECTIONS, GYNAECOLOGICAL INFECTIONS AND G |
| Adult:
1.5-3 g (ampicillin 1-2 g + sulbactam 0.5-1 g) every 6 hr. Dose may be given via deep IM inj or slow IV inj. Max: 12 g (ampicillin 8 g + sulbactam 4 g) daily. |
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| Intravenous |
| HOSPITAL-ACQUIRED PNEUMONIA |
| Adult:
For aspiration, community-acquired pneumonia: 1.5-3 g (ampicillin 1-2 g + sulbactam 0.5-1 g) every 6 hr. For hospital-acquired pneumonia: 3 g (ampicillin 2 g + sulbactam 1 g) every 6 hr. |
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| Intravenous |
| COMMUNITY-ACQUIRED PNEUMONIA |
| Adult:
For aspiration, community-acquired pneumonia: 1.5-3 g (ampicillin 1-2 g + sulbactam 0.5-1 g) every 6 hr. For hospital-acquired pneumonia: 3 g (ampicillin 2 g + sulbactam 1 g) every 6 hr. |
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| Intravenous |
| ENDOCARDITIS |
| Adult:
3 g (ampicillin 2 g + sulbactam 1 g) every 6 hr for 4-6 wk, to be used with gentamicin or vancomycin. |
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| Parenteral |
| SUSCEPTIBLE INFECTIONS INCLUDING RESPIRATORY TRACT INFECTIONS, INTRA-ABDOMINAL INFECTIONS, URINARY TRACT INFECTIONS, SKIN AND SOFT TISSUE, AND BONE AND JOINT INFECTIONS, GYNAECOLOGICAL INFECTIONS AND G |
| Child:
≥1 yr: Usual dose: 300 mg/kg/day (ampicillin 200 mg + sulbactam 100 mg), to be given in 4 equally divided doses. Up to 200-300 mg/kg/day of ampicillin (given in 4 equally divided doses) may be used in infants ≥1 mth of age. Recommended duration of parenteral treatment: Not exceeding 14 days. |
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| Parenteral |
| UNCOMPLICATED GONORRHOEA |
| Adult:
1.5-3 g as a single IM/IV inj. May be used in combination with oral probenecid 1 g. |
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| Parenteral |
| PROPHYLAXIS OF SURGICAL INFECTIONS |
| Adult:
1.5-3 g as a single dose before surgery. Given via IM/IV inj. |
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| Parenteral |
| ACUTE PELVIC INFLAMMATORY DISEASE |
| Adult:
3 g (ampicillin 2 g + sulbactam 1 g) every 6 hr, to be used with doxycycline (100 mg orally or IV 12 hrly). Parenteral treatment may be discontinued 24 hr after clinical improvement; oral doxycycline at 100 mg bid should be continued to complete 14 days of treatment. |
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| Precautions |
Monitor for signs of anaphylaxis during 1st dose. Monitor haematologic, renal and hepatic function during prolonged treatment. Monitor for signs of superinfections with mycotic or bacterial pathogens during treatment. Prolonged use may increase the risk of oral candidiasis. Pregnancy and lactation. |
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Potentially Life-threatening
Adverse Drug Reactions |
Pain at Inj site, thrombophlebitis, diarrhoea, itching, nausea, vomiting, flatulence, candidiasis, fatigue, malaise, headache, chest pain, glossitis, abdominal distention, dysuria, urinary retention, oedema, erythema, epistaxis, mucosal bleeding. |
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| Adverse Drug Reactions |
Fatal anaphylaxis. |
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| Interactions |
Increased risk of rash with allopurinol. Concurrent use with probenecid may delay renal tubular secretion of ampicillin and sulbactam. If used with aminoglycosides - the two solutions should not be mixed and must be administered at different sites. Concurrent use with fusidic acid may decrease the efficacy of penicillins; penicillins should be given at least 2 hr before fusidic acid admin. May increase effects of warfarin. |
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